What is a VDR?
Virtual Data Rooms (VDRs) are secure and reliable ways to access confidential documents in business transactions. VDRs are utilized for due diligence during mergers and acquisitions and also help companies organize and share important documents with investors and other stakeholders. VDRs are also used to store and organize invoices, contracts and other documents for legal purposes, such as litigation or estate planning.
Members should be aware of the procedures and equipment on their vessels equipped with a VDR/SVDR. It is also recommended to replace and upgrade any that are outdated or do not meet the https://www.dataroomstips.info/best-sales-enablement-software minimum safety standards.
The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), binds to the vitamin D receptor (VDR) and retinoid X receptor (RXR) to form heterodimers that act on gene promoter regions known as vitamin D response elements. These genes regulate the expression of proteins involved in a variety of physiologic processes.
The VDR can be located in glial cells and subsets them that form part of the brain. In the primary hippocampal cells of rodents, VDR immunoreactivity was detected in oligodendrocytes. The VDR is also present in human neuroblastoma and astrocytes. The treatment of leukemia cells from HL-60 with 1,25(OH2)2D3 resulted in monocyte-like differentiation and higher VDR levels. This effect was blocked by inhibitors of the PI3K and MAPK pathways. In addition, VDR expression was increased in oligodendrocytes treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce megakaryoblastic leukemia cell maturation.